The effectiveness of intraperitoneal synovial fluid, honey, propolis,vitamin e and olive oil in the prevention of postoperative peritoneal adhesions

Postoperatif adhesions, in the modern life where surgical techniques developed, are important in terms of cost and complications which is main problem that exists. This is experimental study in which peritoneal adhesion prevention by intraperitoneal administration of synovial fluid, honey, propolis, vitamin E and olive oil were used. In our study there are seven groups and each group contains seven rats. Group 1: kontrol group, group 2: synovial fluid, group 3: honey, group 4: propolis, group 5: vitamin E, group 6: olive oil, group 7: vitamin E and olive oil. After these treatments applied to rats, postoperative 14. day relaparotomy done and macroscopic scoring, histopathological examination and biochemically IL-6, GSH and HSP-70 levels were checked. In macroscopic evaluation; it has been seen that vitamin E+olive oil according to the control and propolis group, olive oil according to the control and propolis group, vitamin E according to propolis group decreases adhesions more significantly (p<0,001). In microscopic evaluation; vitamin E according to the propolis group (p = 0,04) reduced fibrosis were seen, in terms of inflammation (p = 0.067) and vascular proliferation (p = 0.159) there were no significant differences. In biochemical evaluation; level of IL-6 at honey and synovial fluid compared to the propolis group (p = 0,001), level of HSP-70 at honey compared to control group (p = 0,011) were decreased more significantly; level of GSH at synovial fluid compared to propolis group were increased more significantly (p = 0,031). As a result in our study; water extracted propolis group in terms of macroscopic, microscopic and biochemically were not effective; olive oil and vitamin E macroscopically, vitamin E microscopically effective so that they can be tried as antiadhesive; honey and synovial fluid can be used as antiadhesive by their anti-inflammatory activity. But more experimental studies should be done by extending time of relaparotomy and higher dosage use.