Pterygiumda actin ile ilgili protein 2/3 kompleks alt bira 2 gen ekspresyonunun analizi

The most important aspects of diagnosing a disease are determining its cause and then attempting to find a treatment. Pterygium is a disorder that isn't completely understood yet and it's described as a growth disorder by some and a degenerative disorder by others. However, several studies have been conducted in this field, and certain factors for this disease have been identified, including UV, virus, growth factors, apoptosis, ECM, MMP, and interleukins. Uncontrolled proliferation of conjunctiva cells onto the cornea, metaplasia, and certain reports of malignant traits have been documented. Furthermore, the ARPC-2 gene has been discovered to play a role in the progression and induction of a certain type of cancer, which is one of the Arp 2/3 complex's subunits that is involved in actin assembly and therefore sustains and maintains cellular integrity, the objective of this paper is to determine how ARPC-2 gene expression relates to pterygium development and formation. The quantitative reverse transcription PCR method was used to determine the rate of gene expression in 18 samples with pterygium and 18 normal conjunctiva of the same eye. The gathered data showed that the expression of ARPC-2 in pterygium has up-regulated (3.24±1,75) compared to normal conjunctiva, although there was not a significant difference between the two groups (p = 0.209). In conclusion the up-regulation of ARPC-2 gene is thought that it may contribute to pterygium development and formation.