Simultaneous determination of sertralin, fluoxetin, citalopram and escitalopram by Capillary Electrophoresis

Capillary electrophoresis is a widely used method for drug analysis in recent years. They have important superiories over other analytical methods. High separation power, easy quantification calculation, short analysis time, use of sample in quite low facility volume, possibility of simple method development and automatic device development are the most important advantages of this method. Simultaneous determination of different drug substances and quantitative analysis can be achieved by capillary electrophoresis method. The purpose of our study was to develop a method has been developed for the determination of sertralin, fluoxetine, citalopram and escitalopram using capillary electrophoresis from antidepressant drugs which have been increasingly used in the last 20 years. In the second step of our study, the developed method was used to determine sertraline in drug preparations. In addition some parameters such as accuracy, precision, sensitivity and linearity were examined for the validation of the method used.