Siglec levels in Sjogren syndrome

Siglecs (Sialic acid-binding immunoglobulin-like lectins) are cell surface proteins receptors by binding mainly to sialic acid. They belong to immunoglobulin-like lectin family. They are often found on the surface of immune cells. Siglecs are known to play a role in the regulation of innate and adaptive immunity. Thirty followed-up patients with primary Sjogren's syndrome (PSS), 30 patients with systemic lupus erythematosus (SLE) and 30 healthy control group were included in this study. In order to measure Siglec-1, Siglec-2 and Siglec-10 levels, serum and saliva samples were taken from a total of 90 participants consisting of PSS, SLE and control group. ELISA measurements were performed in accordance with the operating procedures specified in the kits' catalogs. Data have been evaluated using appropriate statistical analysis and p<0.05 was considered statistically significant. In addition, siglec-1, siglec-2 and siglec-10 expressions were evaluated by immune histochemical staining from salivary gland tissue samples from the patients who diagnosed with PSS and included in the study. It was observed that there was a significant difference between the groups we included in the study only in terms of the Siglec-10 value of saliva (p=0.006). It was determined that this difference was due to the difference between the SLE group and the control group, and the value of the SLE group was higher than the value of the control group (p=0.005 for SLE-Control). According to Chisolm Masson Grading, no significant difference was observed in patients with Primer sjögren's syndrome in terms of pathological grade and serum siglec values (p >0.05). It was found that there was no significant difference between the results of histopathological evaluation of patients with Primer Sjögren's syndrome and serum, saliva, siglec values and activation index value (p >0.05). As a result, it was concluded that siglec levels may change in immune-related diseases, but more detailed and comprehensive studies are needed. Keywords: Sjögren's syndrome, Systemic lupus erythematosus, Siglec