Study the levels of serum glucose‑6‑phosphate dehydrogenase (G6PD) and some biochemical parameters in leukemic patients

In this work, some changes that accompanied the chronic myeloid leukemia disease has been interested. Hematological variations (leukocytes, erythrocytes, and hemoglobin), glucose-6-phosphate dehydrogenase, ferritin, and some elements (iron, sodium, potassium, and zinc) were investigated in the blood and serum of patients. 130 subjects were enrolled in the study, 65 leukemic patients, and 65 healthy controls. The age differences were non-significant between leukemic patients and control group. The count of leukocytes was increased significantly while the count of erythrocytes and hemoglobin were reduced significantly in leukemic patients. The level of serum glucose-6-phosphate dehydrogenase was decreased significantly in leukemic patients. On the other hand, serum ferritin and iron levels were increased significantly and correlated with the count of leukocytes in leukemic patients. The levels of potassium, and zinc were significantly reduced in leukemic patients, while the level of sodium was not changed significantly. In conclusion, chronic myeloid leukemia may associate with anemia, a reduction in the glucose-6-phosphate dehydrogenase, hypozincemia, and hypopotassemia. Glucose-6-phosp