The study of role apelin, glucose, vitamin D and some biochemical parameters in children with KFD

At the current research we attempt to study the change in apelin, vitamin D, and arginase as principal biomarkers in children and teenagers with renal failure (RF) disease. Two groups of control were enrolled according to their age to get an optimum comparison strategy, leaving the effect of age (especially the changes that happen during puberty) out of the study. The results have shown non-significant change of apelin level between patients and control neither in children nor in teenagers. While serum vitamin D level was reduced in RF patients of both children and teenagers compared to the corresponded control, whereas the level of vitamin D was non-significantly differed between children and teenagers. Serum arginase level was increased significantly in RF patients of both children and teenagers compared to control, and the teenagers have shown significant higher levels of arginase compared to children with RF disease. Vitamin D was correlated negatively with arginase in children with RF disease. At last, vitamin D and arginase can be used to monitor the RF cases in children and young people to avoid the health consequences arises from the upregulation of these two parameters, while apelin was found to be unassociated with the pathophysiology of renal failure in children and teenagers.