Synthesis of thieno-dibenzothiophene derivatives via cyclization reactions

Benzothiophene and derivatives have emerged as central candidates for pharmaceutical applications since they show remarkable analgesic, antiinflammatory, antibacterial antiparasitic, antitussive, hypoglycemic, antitumor and/or anticancer activities. They have also important compounds for material sciences. Many synthetic methods have been employed for the synthesis of this heterocyclic compounds and they have also been isolated from different kinds of plants and used to treat different diseases for many years. On the otherhand, there are a few studies for thieno-dibenzothiophenes which may have critical biological properties. In this study, we developed new methodologies for the synthesis of potentially biologically active thienodibenzothiophene derivatives containing fused heteroaromatics. A variety of organic reactions were used for the formation of desired products such as, Sonogashira Coupling Reactions, Electrophilic Cyclization Reactions and Suzuki-Miyaura Coupling reactions. Moreover, all synthesized intermediates and products were characterized by using spectroscopic methodologies.