Prognostic markers in unilateral ureteropelvic junction obstruction

Objective: In the present study, it is aimed to determine the correlation between urine excretion of MCP-1, TGF-ß1 and the severity of the ureteropelvic junction obstruction in operated and non-operated children diagnosed as unilateral ureteropelvic junction obstruction.Material and Methods: The study was performed in Pediatric Nephrology Department of Cukurova University Medical Faculty. Twenty operated and 26 non-operated patients with unilateral ureteropelvic junction obstruction and 22 healthy children within similar ages were included. MCP-1, TGF-ß1 and creatinine were concurrently measured in the urine examples of both patient and health groups. The results were statistically analysed in Cukurova University, Faculty of Medicine, department of Biostatistics.Results: The ratio of urine MCP-1/ creatinine and TGF-ß1/creatinine was statistically higher in operated patients compared to non-operated patients and healthy children (p<0,05). No statistical difference was found between the non-operated and control groups (p>0.05). There was no significant correlation between the ratio of urine MCP-1/ creatinine, TGF-ß1/creatinine and antero-posterior diameter of pelvis (p>0.05). Urine levels of TGF-ß1 was correlated with antero-posterior diameter of pelvis (p<0,05).Conclusion: Urine MCP-1 and TGF-ß1 might be used as prognostic markers in the follow-up of children with unilateral ureteropelvic junction obstruction particularily for determination of the time of the surgery.Key Words: Ureteropelvic junction obstruction, urine MCP-1, urine TGF-beta1,urine creatinine