Development of new methodologies for the synthesis ofthieno[3,2-a]carbazole

Heterocyclic compounds, with their specialities, constitute an important class which is very important for both material and drug chemistry. There is heterocompounds in almost all of modern day medicine in use worldwide. Among those, the derivatives of carbazol, benzofuran and benzothiophen which contain nitrogen, oxygen and sulphur are also important classes. Notedly, carbazole and derivatives have emerged as central candidates for pharmaceutical applications since they show remarkable analgesic, anti-inflammatory, anti-bacterial antiparasitic, antitussive, hypoglycemic, antitümör and/or anticancer activities. On the otherhand, there are a few studies for tiyenocarbazoles which may have critical biological properties. Tiyenocarbazoles are bioisoters of pyridocarbazoles which have a broad range of biological activities including anticancer, antibacterial and antifungal properties. In this study, we developed new methodologies for the synthesis of potentially biologically active tiyenocarbazole derivatives. In the present study, thieno[3,2-a]carbazole were synthesized via electrophilic cyclization reactions and ring-closure reactions. All derivatives have been characterized by using spectroscopic methods. Moreover, we proposed possible reaction mechanism for the formation of thienocarbazole isomers.