Development of reverse iontophoresis method for non-invasive determination of troponin T, troponin L and hemoglobin A1c

Major Cardiac Events and Acute Coronary Syndrome Cases are among the most important causes of death on a global scale and it is predicted that for a long time it will continue to be the most important cause of death. According to World Health Organization data, it is estimated that 17.5 million people died due to cardiovascular diseases in 2018 and this figure constitutes 30% of global deaths. According to the same data, 7.6 million of these deaths are due to acute myocardial infarction (MI) and 5.7 million are due to stroke. 80% of deaths occurred in low and middle income countries. If appropriate measures are not taken, approximately 20 million people will die of cardiovascular disease, especially MI and stroke, by 2020 each year. In our study, to assist in the development of preventable cardiovascular disease prevention strategies for such an important problem, the development of non-invasive analysis methods for the determination of some compounds and biomarkers that can be used in the diagnosis, monitoring and estimation of the mentioned cases and the analytical method validation studies have been made. The aim of our thesis; was to develop non-invasive analysis methods that continuously monitor some physiological parameters and biomarkers; different from current conventional MI diagnostic methods. Thus, for the first time, non-invasive determination methods will be developed and compared with conventional determination methods.