Inflammatory markers in neonatal sepsi̇s

Despite the development in recent years, neonatal sepsis continues to be one of the most important reason of the mortality and morbidity. Due to the fast and deadly in neonatal sepsis, clinical diagnosis should be made early and treatment is started early. Today, the diagnosis is made by the blood culture. However, there sults of blood cultures being forced to wait for at least 24-48 hours, antibiotics to be given to them other before birth, blood culture taken be for antibiotics have started the baby, taken for cultures not inshort supply of blood, the low density of the bacteria, bacteremia in neonates, particularly in the early stages of infection to be temporary and short term pathogenic microorganisms in blood cultures of neonatal sepsis may inhibit detection and in cases of sepsis a cultur makes it impossible to prove. Therefore, also for the diagnosis of neonatal sepsis based on clinical and laboratory diagnostic method shave been proposed. Infection Control Committee of the United States by the non-negative cultures or blood culture, newborns with clinical sepsis 'clinical sepsis' have been defined. Our aim is to investigate some markers for the early diagnosis of neonatal sepsis. 50 healthy newborn babies and 50 babies with the diagnosis of clinical sepsis in the newborn intensive care unit were taken into the study in Elazığ Training and Research hospital. Before starting the study, Ethics committee judgement was taken and the approval forms were signed by the families showing their willingness. The patients were evaluated according to their stories , physics and their laboratory tests . Patients with 10 points and scoring them according to the Tollner system create a working group. The control group consisted 0-5 points. In all cases, complete blood count, C- reaktive protein (CRP) and procalsitonin (PCT) were studied cell surface antigens. Using flow cytometry for cell surface antigens, Cluster of Differantion (CD) 64, CD11b, CD62L and Human Leukocyte antijen-DR (HLA- DR) by working, monocytes and granulocytes levels were evaluated separately. As a result, compared to CRP and PCT patients and control groups were statistically significant. When monocytes and granulocyte levels were statistically evaluated markers of CD11b, CD64 and HLA-DR were significantly for travelers between groups (P<0.05). There was also no significant difference for CD62L on monocytes and neutrophils (p>0,05). Finally they reached the conclusion that; CRP and PCT acute phase proteins, CD11b, CD64 ve HLA-DR surface antigens could be a new method in the early diagnosis of neonatal sepsis.