Comparison of the inflammation-based prognostic score with patients in intensive care and have respiratory failure

ABSTRACT Aim: Determination of prognosis is very important for the patients who admitted to intensive care unit. Respiratory failure which is an important cause of morbidity and mortality is common this patient population.inflammation based prognostic scoring systems such as glasgow prognostic score, platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio and porgnostic index(PI) are used to determine prognosis in these patients. In this study; we aimed to determine the prognosis of the patients who were admitted to intensive care unit and had respiratory failure by using these inflammation based prognostic scoring systems and evaluate the impact of these parameters on mortality and length of hospital stay. Materials and methods: 511 patients with respiratory failure who was admitted to Dicle Universtiy Research Hospital Internal Intensive Care Unit and Respiratory Intensive Care Unit between 2010 and 2015 years were enrolled to this study. the study was designed retrospectively. the demographic characteristics, etiologies, comorbid diseases and laboratory findings of patients were taken from patient files. the length of stay in intensive care unit and results were recorded. Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) were calculated. patients were divided into two groups as patients who died (group 1) and patients who living (group 2). we compared the prognostic parameters between two groups. Results: There were 412 patients in group 1 and 99 patients in group 2. in group 1, WBC,neutrophil, CRP, PLR and NLR values were statistically significantly higher compared with group 2 ( p<0.05). length of stay, platelet and albumin values were statistically significantly lower in group 1 than group2 (p<0.05). there was a positive correlation between higher NLR, PLR and mortality rate. mortality rate was higher in patients with NLR≥5 and/or PLR>300. we found that patients with NLR≥5 and patients who classified as PI group 2 had longer length of stay and worsened overall surival. Conclusion: In this study; patients with higher NLR and PLR who were followed at intensive care unit with the diagnosis of respiratory failure had higher mortality rate. Also we found that patients with NLR≥5 and patients who classified as PI group 2 had longer length of stay . Key words: Mortality, NLR, PLR, respiratory failure