Analysis of ubiquitin C-terminal hydrolase-LI levels in ischemic and hemorrhagic cerebrovascular disease patient presented to the emergency department

Somnolence is a significant part of all complaints in emergency room applications. Cerebrovascular diseases (CVD) and metabolic disorders are among the significant underlying reasons in patients that apply to emergency services with somnolence. The objective of the present study is to investigate the relationship with diagnosis, prognosis and mortality of ubiquitin c-terminal hydrolase – L1 (UCH-L1) levels in non-traumatic CVD patients and its comparison with healthy control groups and groups with somnolence due to metabolic reasons, due to the specificity of c-terminal hydrolase – L1 to neurons, its prevalence in high levels and the increase observed in neuropathologic pictures. 80 ischemic CVD, 40 hemorrhagic CVD, 80 metabolic somnolence patients, and 40 healthy control group, a total of 240 individuals who volunteered to participate in the study participated in the present study. The findings of the study showed that UCH-L1 levels were higher in ischemic CVD patients compared to patients with metabolic somnolence (p = 0.004). Furthermore, UCH-L1 levels were identified as higher in hemorrhagic CVD patients than patients with metabolic somnolence (p = 0.002). As a result, it was concluded that UCH-L1 could be used as a marker in distinguishing ischemic and hemorrhagic CVD with patients who suffer metabolic somnolence. Keywords: Ischemic cerebrovascular disease, hemorrhagic cerebrovascular disease, ubiquitin c-terminal hydrolase – L1, metabolic somnolence.