Lack of vitamin B12 in the 1-20 months following the break 40 infant patients and treatment outcomes in terms of psycho social motor retardation

SUMMARYIt is known that Vitamin B12 deficiency have the negative effects on the central and peripheral nervous system, the gastrointestinal system, cardiovascular system, musculo-skeletal system, hematological and immunological systems. In our country, However there are many studies about the effect of iron deficiency on psycho-social motor gerilik development, there are very few comprehensive studies about effects of vitamin B12 deficiency on the psycho-social motor retardation in children. In our Region, because of the high incidence of psycho-social motor gerilik development problems that as a result of vitamin B12 deficiency. We designed as a prospective study with 40 case between the ages of 1-20 months with B12 deficiency and 40 mothers who accepted to study. At the beginning and at 3-6 months after treatment, patients? hematological measurements, blood B12 levels, blood folate levels were measured, and DENVER-II test which evaluate psycho-social motor retardation development of children was performed. Also mothers ` blood vitamin B12 levels and blood folate levels were measured.At 3-6. months after treatment we found that in a short time the treatment of patients with cobalamin responsive and psycho-social motor retardation development was significantly improved by neurological examination and Denver-II test.Our study is a importand study because of it is a rare one of the few comprehensive studies that investigate the effects of vitamin B12 deficiency on psycho-social motor retardation development, Also it is a rare study which use DENVER-II test for determination of psycho-social motor development retardation.As a result; vitamin B12 deficiency may causes psycho-social motor gerilik retardation in children and In the early period as 3-6 months, mental and motor development is significantly improved by the treatment of vitamin B12 .Keyword: Psycho-social motor development retardation, DENVER II test, Vitamin B12