Biochemical studies of thyroid hormones, anti thyroperoxidase, and some parameters in blood serum of patients of benign and malignant breast tumor patients

This study was conducted at the Oncology Teaching Hospital in Baghdad - Iraq, and the study lasted for 7 months, from March 1, 2021, to September 1, 2021. The study included three groups, each group included 40 patients with benign tumors, 40 patients with malignant tumors, and 40 female control groups. Thyroid disease is a common disease that may lead to other diseases. Breast cancer is also a common and fatal disease, and the causes of the disease must be sought. Thyroid peroxidase (TPO) is required for the thyroid gland's physiological activity. The goal of this study is to see if there's a link between thyroid and lipid problems and benign breast disease and breast cancer. The high incidence of thyroid peroxidase antibodies (TPOAbs) in breast cancer patients, as well as their protective effect, have previously been shown, implying a relationship between breast cancer and thyroid autoimmunity. TPO was recently discovered in breast cancer tissue samples, however, its antigen was not examined. TPO and its antigenic activity may have favorable benefits on TPOAb-positive breast cancer patients by detecting thyroid pathophysiology early. However, further research is needed to establish TPOAbs' positive impact and to better understand the mechanism behind it.