The relation between vitamin D receptors (rs2228570) polymorphism and prostate cancer

AIM: To investigate the association between the vitamin D receptor (VDR) gene rs2228570 polymorphism and prostate cancer (PC) and Reduce risk in the Turkish population. MATERIAL and METHODS: The SNPs of the VDR gene rs2228570 will be genotyped using TaqMan SNP Genotyping Assays and BioScience (ABI) 7500 real-time PCR system. The statistical analysis was carried out using SPSS version 26.0. This research project will be a case-control retrospective study comprising 69 patients with prostate cancer and a control group which consisted of 63 healthy individuals. RESULTS: In this study, VDR gene (rs2228570) polymorphism was analyzed in patients with PC and the control group. There was no significant difference obtained from this study regarding genotype analysis (p=0.475). In the patient group, the genotype frequency of homozygous wild type (AA) was 4.6%, heterozygous genotype (AG) frequency was 41.7%, and homozygous mutant genotype (GG) was 53.9%. In the control group, the genotype frequency of homozygous wild type (AA) was 8.3%, heterozygous genotype (AG) frequency was 40%, and homozygous mutant genotype (GG) was 51.7%. CONCLUSION: It is the first study that investigates the relationship between VDR gene variation (rs2228570) with prostate cancer susceptibility in Turkish populations. The limited sample size could be a limitation of the study. Thus, new studies with larger populations should be conducted with the VDR polymorphism to show the effect of VDR on PC susceptibility. Keywords: Vitamin D, Prostate cancer, (VDR) gene (rs2228570) polymorphism