Investigation of irisin, orexin, adiponectin and leptin levels with oxidative processes in ischemic and hemorrhagic serebrovascular diseases

The clinical importance of imaging methods, as well as biochemical indicators in diagnosis and indication of prognosis of Cerebrovascular diseases (CVD) increase continuously. In the present study, the aim of this study was the investigate the relationship of irisin, adiponectin, leptin and orexin levels to oxidative processes in cerebrovascular diseas and the relations between Glasgow coma scala (GCS), The National Institutes of Health Stroke Scale (NIHHS) and Modifiye rankin scala (MRS).In the present study, the aim of this study was to investigate the relationship of iris, adiponectin, leptin and orexin levels to oxidative processes in cerebrovascular diseases. 60 ischemic and 60 hemorrhagic CVD patients and a control group of 60 healthy volunteers, a total of 180 individuals were included in the study. In our study, serum iris (control group: 4,11 ± 0.86 μg / ml, ischemic CVD: 3,62± 1,06 μg / ml p<0.05), hemorrhagic CVD: 3,61 ± 0, 98 μg / ml P <0.05) ), orexin (Control group: 353,62 ± 70,94 ng / L, ischemic CVD 311,90 ± 68,18 ng / L (P <0.05), hemorrhagic CVD: 304,23 ± 62,13 ng / L (P <0.05) ) and adiponectin (control grubu: 22,84 ± 4,89 mg/L, ischemic CVD: 17,26 ± 3,98 mg/L (P<0.05), hemorrhagic CVD: 18,62 ± 3,43 mg/L (P<0.05) ) levels were significantly lower in the CVD group than in the control group. Serum leptin (control group: 16.03 ± 7.67 ng / ml, ischemic SVH: 23.34 ± 8.20 ng / ml (P <0.05), Hemorrhagic SVH: 22.57 ± 9.84 ng / ml (P <0.05) ), TAS (Control group: 1,20 ± 0,19 μmol Trolox equivalent / L, Ischemic CVD: 1,30 ± 0,15 (P <0.05), hemorrhagic CVD: 29 ± 0.15 (P <0.05) ) and TOS (control group: 3,79 ± 0,54 μmol H2O2 equivalent / L, ischemic CVD: 4,11 ± 0,44 (P <0.05) and hemorrhagic CVD: 07 ± 0.66 (P <0.05) ) levels were significantly higher in the CVD group than in the control group. Serum iris, orexin, adiponectin, leptin, TAS and TOS levels were not significantly different between the ischemic and hemorrhagic CVD groups (p> 0.05). There was no correlation between GCS, NIHSS and MRQ and iris, orexin, adiponectin, leptin, TAS and TOS. In conclusion, the serum levels of iris, orexin, and adinopectin were lower in ischemic and hemorrhagic CVD compared to the control group, and the serum levels of leptin, TOS and TAS were higher in ischemic and hemorrhagic CVD than control group suggesting that these biomarkers could be used for CVD. Keywords: Cerebrovascular disease, irisin, orexin, adiponectin, leptin, tas, tos oxidative processes