Chiral ferronce Schiff base ligands use molecular diagnostics and nmr spectroscopy with T1 and T2 relaxation times and measurement of connecting calculate

Molecular recognition; hydrogen bonding, metal coordination, hydrophobic forces, Van der Waals forces, π-π interactions, electrostatic and/or electromagnetic effects, such as through non-covalent bonds between two or more molecules means that a specific interaction. The most important of chirality studies which is the main theme of modern chemistry is result of interaction with other molecules Since the 1960's, NMR T1 and T2 relaxation times measurements are made in various protein solutions. However, the studies related the calculation of binding constants based on measurements of relaxation times have been started in recent years. Chiral ferrocene ligands are distinct classes of stereo selective synthesis compositions and their development is very fast. Ferrocene carboxaldehyde and the study of the schiff base derived from their metal complexes have been quite interesting. The importance of ferrocene in the asymmetric synthesis, the many ferrocene derivatives as chiral catalystsis owing to quite successful In this study, the molecular recognition properties of chiral ferrocene schiff bases ligands synthesied were analyzed by 1H NMR method and having information about binding constants were obtained from T1 and T2 relaxation times. Such studies are fairly new and the limited number, therefore It is worth to calculate of binding constants by this method. Association constants of the chiral ferrocene for R or S enantiomer were calculated from linearization fitting obtained from varying concentrations of each enantiomer against 1H NMR chemical shifts in the presence of a constant ferrocene concentration. Binding constants of chiral ferrocene complex formation with R and S phenylethylamine enantiomers are calculated as Ka:265.96x10-3M-1 and Ka: 273.70x10-3M-1, respectively. Both binding constant of Lee Fielding's (2007) research Ka < 105 based on the findings can call to poor connect. However, indicate that S phenylethylamine of the complexes formed by the enantiomer R phenylethylamine to connect more strongly. 1 / T1, S and R phenylethylamine graph plotted against the concentration (Fig 4.12-4.17) confirms this result.