The correlation between histamine level and cytokines in patients with chronic urticaria

The clinical history in search of the possible causal factors and significant aspects of the origin of urticaria is the basis of the diagnosis, being necessary to take into account the psychic components and psychiatric disorders such as depression, anxiety and emotional distress that are appreciated especially in children. If there is no apparent cause, it will be necessary to guide the patient or the child's guardian to make a food diary, keep track of the consumption of medications and record of activities; Complementary tests will always be carried out based on clinical data. It is important to consider that the underlying causes of chronic urticaria do not appear to be different between children and adults, except possibly in infants. Despite the need for more epidemiological studies in children, it is increasingly evident that the differences between the causes of urticaria in children and in adults are small. A range of chemicals, such as food, containers, scents, plant and animal products and metals may lead to the syndrome of contact with urticaria. Since exposure to causative hives may be like exposure to contact irritants, care must be taken that the workplace of the patient and domestic exposures are explored.