Comparison of ADC (apparent diffusion coefficient) values in Breast Magnetic Resonance Imaging with Immunohistochemical Markers in Patients with Breast Cancer

The aim of this study was to determine the relationship between ADC values in breast MRI with immunohistochemical markers and hormone receptor status in breast cancer patients and also to reveal T2 intensity, shape, margin, size, lymph node involvement, grade, multifocality, multicentricity, bilaterality and enhancement pattern differences between subtypes of tumours. In this study, 141 patients who underwent breast biopsy in the Department of Radiology of Hacettepe University Faculty of Medicine were included between January 2010-June 2018. Patients were divided into receptor subgroups according to hormone receptor status, molecular subtypes according to hormone receptor status, grade and Ki-67 index and pathological main subtypes. Tumor degree, enhancement patterns, age of the patient, side of the mass, lymph node involvement, ADC values, BI -RADS classification, bilaterality, multifocality, multicentricity, margin, shape, T2A intensity were evaluated for these subtypes. ADC values were higher in patients with triple negative tumors than Luminal A and Luminal B tumors. ADC values were higher in triple negative tumors than in ER+, PR + and HER 2 -tumors. Lymph node involvement was found to be lower in ER +, PR +, HER 2-group, which had lower ADC values than triple negative tumors. Rim enhancement was significantly higher in triple negative tumors. Circumscribed margin in both hormone receptor subgroups and molecular subgroup classification was higher in triple negative tumors. In conclusion, ADC values may give information about the course and the type of the tumor.