Analyzing the effect of cardiopulmonary bypass duration over the postoperative renal functions in patients who undergo mitral valve surgery

Aim: Acute renal injury following cardiac surgery results in the increased rates of mortality and morbidity. The aim of this study was to investigate the impact of cardiopulmonary bypass (CPB) duration over the renal functions. Material and Methods: Eighty patients who had undergone mitral valve surgery via median sternotomy at the Heart and Vascular Surgery Clinic of Tekirdag Namık Kemal University between 2010 and 2019 were investigated in terms of age, gender, preoperative and postoperative serum urea and creatinine counts, type of surgery and CPB duration. Independent samples t and Chi-square test were used for statistical analysis. Results: Mean age was 56.8±10.7 years among the study group including 25 (%31.3) males and 55 (%68.7) females. Mean preoperative serum urea and creatinine counts were 40.6±17.3 and 0.91±0.25 mg/dl whereas mean postoperative counts for the same variables were 45.2±16.9 ve 1.1±0.36 mg/dl, respectively. The most frequently applied mitral valve surgery was the mitral valve replacement (n= 55, %68.8). Mean duration of CPB was 85.6±17.3 (range= 60-137) minutes. All the patients were at stage 1 according to postoperative evaluation of renal functions via AKIN (Acute Kidney Injury Network) classification. Prolonged duration of CPB was significantly related to the elevated levels postoperative serum urea and creatinin (P< 0.05) Conclusion: Efforts to shorten the duration of CPB will be beneficial to prevent acute renal injury that may develop following mitral valve surgery. Keywords: Mitral valve surgery, cardiopulmonary bypass duration, renal function, acute reanal injury