Periodontitiste WAVE1 gen ekspresyonunun analizi

Periodontitis is a multifactorial inflammatory autoimmune disorder characterized by disruption of the periodontium. It is a result of the interaction between host inflammatory response and supra- and sub-gingival biofilms produced by periodontopathic bacteria. The condition depends on multiple interacting risk factors, including: genetic, microbial, environmental, and immunological factors, as well as race, gender, and age. To date, specific genes directly involved in periodontitis have not been described. WASP verprolin-homologous protein 1 (WAVE1) is one of the essential actin-cytoskeleton rearrangement proteins that is primarily expressed in neuronal cells. It is a very crucial molecule in the regulation of tumor growth, invasion and metastasis. The role of WAVE1 protein in the control of actin polymerization by activation of the ARP 2/3 complex seems to be important in the formation of actin-based membrane protrusions that are observed in cell migration. The current study is the first to investigate the relationship between periodontitis and WAVE1. In this study, 18 periodontitis patients (10 male and 8 female) were recruited in order to analyze the mRNA expression of WAVE1 gene in periodontitis tissues. They had a mean age of 53.1 years (34-65). The quantitative real time PCR (qPCR) method was used to evaluate the gene expression level in periodontitis and healthy tissues of each patient. The analyzed data showed that WAVE1 was overexpressed in periodontitis tissues when compared to healthy control tissues and the difference was statistically significant (p = 0.0442). One of the limitations of this study was that it had a small sample size. In conclusion, WAVE1 does have a significant role in the development and progression of periodontitis.