Nesfatin-1 levels and metabolic parameters in polycystic ovary syndrome patients

Nesfatin-1 is hormon synthesized in hypothalamus and several other specific organs regulating eating habits, appetite and is thought to be related to ovarian functions. In our study, we aimed to evaluate nesfatin-1 levels with the other metabolic parameters in the polycystic ovary syndrome, a condition that is known to be related to both ovarian functions and obesity. Study subjects were chosen from the women who applied to the Obstetrics and Gynecology Department of Istanbul Bilim University Avrupa Florence Nightingale Hospital. Thirty-five healthy control subjects and 55 PCOS patients were included. Blood samples were obtained in the 3rd-4th days of the menstrual cycle. Luteinizing hormone, Follicle-stimulating hormone, Free testosterone, Dehydroepiandrosterone sulfate, Insulin, Fasting blood glucose, High density lipoprotein, Low density lipoprotein, Triglycerides, Sex hormone binding globulin levels were measured; homeostatic model assessment - insulin resistance value was calculated. Nesfatin-1 levels were measured by a competetive inhibition ELISA method. Due to our results, PCOS patients were having lower nesfatin- 1 levels compared to the control group. This was thought to be related to the BMI difference between patient and control groups, so the groups were divided into subgroups according to their BMI intervals; after all, although the nesfatin-1 results were seemed to be independent of the BMI, we emphasize the necessity of the repetition of similar study with larger subgroups.