Investigation of the antioxidant and antitumour properties of some cyclobutane ring containing 2,5-thiophene diacyl compounds.

In this research, the effect of tiophene derivatives on the MDA concentration which is an indicator of Lipid peroxidation, antioxidant vitamins A, E and in vitro antioxidant activity and antitumour activity were investigated in cell culture media.In the comparison done among groups, it was observed that MDA and vitamin A concentrations were statistically (P<0.05) changed. Looking at the measured parameters during the experiment, the number of live cells, the compounds is seen an effective antitumour activity in the L 1210 cell types.In conclusion, the parameters measured here in the show that all used compounds caused a considerable oxidative stress.