Mean corpuscular volume, mean platelet volume and serum level of the soluble CD 40 ligand in patients with ischemic and hemorrhagic cerebrovascular disease

Cerebrovascular diseases (CVD) are most prevalent reason for mortality, and loss of labor in the world. The clinical importance of biochemical indicators, as well as imaging methods in diagnosis and indication of prognosis of CVD increase continuously. The objective of the present study is to identify soluble-CD40 ligand, mean platelet volüme (MPV), and mean corpuscular volüme (MCV) levels in ischemic and hemorrhagic CVD, and to determine the relationship between these parameters and prognosis and mortality. 100 ischemic and 80 hemorrhagic CVD patients and a control group of 50 healthy volunteers, a total of 230 individuals were included in the study. Mean age of patients included in the study was 67,7±13,5 and 50.6%(n=91) were males. It was determined that there was no significant difference between patient and control groups on sCD40L and MCV levels, however levels for patients with ischemic CVD (9±0,9fl) (p:0,000) and hemorrhagic CVD (8,8±1,2 fl) were significantly higher than the control group (8,3±0,8fl). The rate of exitus among SVH patients was 22.2%(n=40). It was determined that sCD40L levels for exitus patients (3,56 ± 2,11 ng\ml) significantly decreased when compared to sCD40L levels for living patients (5,01± 4,03 ng\ml) (p=0,003). As a result, the findings of the study determined that, albeit the serum MPV levels were higher when compared to control group, MPV and MCV levels did not differ significantly among the living and exitus patients, however sCD40L levels were significantly lower in exitus patients. Keywords: Cerebrovascular disease, mean platelet volume, mean corpuscular volume, soluble CD40 ligand.