Amidoksimlerin fenilboronik asit ile halka kapanma reaksiyonları

The aim of this work is the synthesis of 3,4,5-trisubstituted-4,5-dihydro- 1,2,4,5-oxadiazaborole heterocycles by the cyclodehydration reactions of mono and N-substituted amidoximes with phenylboronic acid. They have been reported to have hypotensive, cardiac, and central nervous system depressant activities. For this purpose, first, amidoximes as starting compounds were synthesized according to the literature procedures. The amidoximes were then reacted with phenylboronic acid to give 3,4,5-trisubstituted-4,5-dihydro-1,2,4,5- oxadiazaborole heterocycles. All of the compounds newly synthesized were identified by means of spectral measurements (IR, NMR, MS, X-Ray) and physical constants (e.g. melting points, Rf values) and in this regard, this work is an important contribution to the synthetic organic chemistry. Keywords: Amidoxime, Phenylboronic acid, Cyclodehydration reaction, Oxadiazaborole, Spectroscopy, Hammett constant, Substituent effect.