Synthesis, characterization and investigation of biological properties of Bismuth(III) halide complexes of some thiosemicarbazone derivatives

Thiosemicarbazones and metal complexes of thiosemicarbazones have an important place due to their biological activities such as antibacterial, anti-tumor, anti-cancer, anti-viral, anti-malarial and anti-fungal. Bismuth compounds have been widely used in the medical field for centuries in the treatment of various diseases. It is also known to be used in different fields such as alloys and cosmetics. In this thesis study, the reactions of some thiophene thiosemicarbazone derivatives, thiophene-2-carbaldehyde thiosemicarbazone, thiophene-2 carbaldehyde-N-methyl thiosemicarbazone and thiophene-2-carbaldehyde-N-ethyl thiosemicarbazone, with 6 new bismuth(III) halides (BiX3; X: Cl, Br, I) compounds were synthesized. The chemical structures of these synthesized compounds were elucidated by elemental analysis, UV-Vis spectroscopy, 1H and 13C-NMR spectroscopy, FT-IR spectroscopy, FT-Raman spectroscopy, and thermogravimetric and differential thermal analysis methods. In addition, the crystal structures of thiophene-2-carbaldehyde-N-methyl thiosemicarbazone, thiophene-2-carbaldehyde-N-ethyl thiosemicarbazone and all synthesized bismuth(III) halide compounds were determined by single crystal X-ray diffraction analysis. Bismuth complexes's were tested cytotoxic activity against adenocarcinoma (MCF-7) cells. The antibacterial activities of the complexes and their ligands were tested against gram-negative species (Pseudomonas Aeruginosa (ATCC 27853) and Escherichia Coli (ATCC 25922)) and gram-positive species (Staphylococcus Epidermidis (ATCC 35984) and Staphylococcus Aureus (ATCC 25923)).