Biochemical study for the role of serum uric acid and catalase in monitoring the control of glycemia in type 2 diabetic patients

This study has aimed for investigating the role of uric acid in different groups of glycemic controlled patients with (T2DM). The interest was involved zinc and catalase as antioxidant materials to declare their role in T2DM disease. The study has included 75 patients with T2DM disease whom divided equally on three subgroups according to their glycemic control, which named poor glycemic control, fair glycemic control, and good glycemic control, and additional 25 people were healthy to control the study. According to the findings, persons with T2DM who have poor glycemic control had significantly higher levels of uric acid, which accompanied with a decrease in the level of zinc and catalase compared to the healthy people. Significant changes in the lipid profile characteristics have been seen in people with T2DM. Glycemic control is not being properly maintained T2DM patients have showed a positive link between uric acid and cholesterol, whereas fair glycemic control T2DM patients have demonstrated a positive correlation between uric acid and fasting glucose level. In conclusion, poor glycemic control associates with increase in the uric acid level and decrease in the antioxidants.