Smart polymers as in biomedical applications and improvement of characterization technique by qcms

The aim of this project is to perform the characterization of smart polymers with a new approach, quartz crystal microbalance systems (QCM), faster, easy to apply system with real-time and sensitive measurement and without indispensability of purpose that is requirement because of the iterative procedures, and to demonstrate the applicability of the performed method with drug release system.First the frequency measurements are accrued with QCM as the results of the swelling and disswelling behavior at different pH values (pH:5, pH:6, pH:7, pH:9) of the prepared as different concentrations xanthan gum hydrogels (5 g/l, 10 g/l, 20 g/l). After that the mass changes are calculated via the frequency measurements. Then the same procedures are applies for the different temperature values (40OC, 60OC, 80OC).For the application of drug release system, the insulin solution at pH:7 is permeated as the result of the swelling behavior of the hydrojels. Then pH value of the medium is changed and the permeated insulin solution released from inside the hydrojels. The masses of permeated and released insulin solutions are calculated via the frequency measurements.