The correlation between serum vitamin D and occyte quality, potential of fertilization and embryo development in the assisted reproductive technology (ART) cases

There is increasing interest in vitamin D research as a result of the increased incidence of vitamin D insufficiency. Vitamin D deficiency has been associated with a number of acute and chronic disorders. There is increasing evidence that 25-hydroxy[25(OH)] vitamin D has important effects on a variety of systems, including the human reproductive system. Vitamin D can help regulate the menstrual cycle, endometrial proliferation, follicular development, relief of early dysmenorrhea, and decrease vaginal fibroid. Studies show that women with high levels of vitamin D in their blood are more likely to conceive. The aim of this study is to show whether there is a relationship between 25 (OH) vitamin D blood levels and oocyte quality, in vitro division success and embryo quality in IVF patients. Individuals who underwent IVF treatment at a health center in Misurata, Libya between January 2018 and December 2020 were retrospectively analyzed. Luteinizing Hormone (LH) levels of the patients were recorded before and after the treatment. All patients in the study were administered vitamin D at a dose of 1,500 to 2,000 IU (3 sprays per day) for two months after treatment was started. A statistically significant difference was found in LH levels before and after treatment. However, no significant difference was observed between vitamin D supplementation and oocyte quality, in vitro division success and embryo quality. In this study, it was shown that vitamin D supplementation did not affect women in infertile marriages. Additional studies are needed to see in more detail whether vitamin D supplementation will help in vitro fertilization success.