Erkek sıçanlarda kısmi sol koroner arter tıkanmasını takiben oluşan aritmiler üzerine ATP bağımlı potasyum kanal bloker ve açıcılarının etkisi

More than 50 % of Sudden Death in human being occurs due to heart attack that is generated by occlusion of coronary arteries. The reason of these sudden death is ventricular arrhythmia that occurs due to the myocardial ischemia. That?s why experimental studies have been done for the prevention or decreasing of these arrhythmias. Researches were concentrated on the ATP dependent potassium channels that have role in the generation of these arrhythmias. In this study, unlike previous studies; the effect of both ATP dependent potassium channel blocker and opener on ischemia induced arrhythmia were researched in rats having smaller infarct size.In the present study, 280-377 g weight, 8-9 months old, 21 Spraque-Dawley male rats were used. Pinacidil was given intravenously and glibenclamide was given intraperitoneally before coronary ligation. Electrocardiogram and blood pressure were recorded during 30 minutes of coronary ligation.Blood pressure decreased in all animals after coronary ligation. Glibenclamide increased the incidence of arrhythmia during 30 minutes of coronary ligation but there was no statistical difference observed. Similar insignificant effect was seen in pinacidil treated groups. Similarly arrhythmia score calculated from duration and type of arrhythmia was not significantly different in pinacidil and glibenclamide treated group according to control rats.As a result, the effect of pinacidil and glibenclamide on the arrhythmias induced by smaller ischemic area in male rats were different as it compared with larger ischemic model. This different effect may be due to the presence of less number of ATP dependent potassium channels and the appearance of less arrhythmia in males than females.