Immunological and microbiological study of urinary tract infection patients

Urinary tract infection (UTI( is one of the widest bacterial infections in humans. The prediction of Urinary tract infection (UTI) and finding specific pathogens requires the identification of biomarkers that are more precise because their list has been extended. This study aims to identify common bacterial causative agents of urinary tract infection (UTI) and assess some biomarkers and clarify the relationship between bacterial pathogens and concentrations of these biomarkers. subjects in this research were (100) adult patients suffering from Urinary tract infection (UTI), In addition to (20) apparently healthy 10.33as a control group Midstream urine and blood samples were collected from patients and the control group. All included markers (Il-6, IL-8, and CRP) were notably higher in patients than in controls. The mean of IL-6 and IL-8 levels in patients was 413.7 ± 467 pg/mL and 160.2 ± 251.4 pg/m respectively compared with 23.11 ± 10 pg/mL and 11.1 ± 5.6 pg/mL respectively in the control group. Similarly, the mean levels of CRP in patients was 27.5 ± 12.7 mg/L which is extreme elvaed than of controls 10.7 ± 3.9 mg/L. with highly signifcant difference. The study showed no effect of sex on the high level of (IL-6 and IL-8) between males and females, as the study did not show a significant effect and that the immune response depends on the pathogen and the strength of the body's immune response against the same pathogen. The urinary tract infection (UTI) is one of the most wide spread location of bacterial infection in humans. The prediction of Urinary tract infection (UTI) and finding specific pathogens rquires the identification of a biomarkers which is more precise because their list have been extended. This study aims to identify common bacterial causative agents of urinary tract infection (UTI), to assess some biomarkers and to clarify the reltionship between bacterial pathogens and concentrations of the biomarkers. Bacterial Profile in Patients Escherichia coli isolated from 34% of patients. Streptococcus fecalis was isolated from 23% of patients, Klebsiella pneumonia isolated from 14% of patients, Staphylococcus saprophyticus isolated from 12% of patients followed by proteus mirabilis 5%. staphylococcus aureus 7%. Pseudomonas aeruginosa was isolated from 5 % of patients. Keywords: Urinary tract infection, Microorganism, Immunity response