The inhibition effects investigation of metal complexes with coumarin Schiff base on 6PGD activity

This work is focused on the 6PGD enzyme. Without 6PGD, cancer cells are unable to thrive or spread. The beginning or course of cancer is not affected by a 6PGD shortage of less than one percent. Delaying or stopping cell growth and division may have a detrimental effect on the development of cells. Definition of cancer-based glucose metabolism, cancer cells depend on 6PGD to produce NADPH and DNA. When 6PGD is inhibited, it reduces NADPH production as well as DNA synthesis. OPP enzymes are now being considered as prospective therapeutic targets because of their close ties to tumor metabolism. In this research, some Schiff bases and their metal complexes were tested to determine their inhibitory effects on the 6PGD enzyme. The increase in NADPH at 340 nm was utilized to measure the activity of the enzyme. Pd(3MeOCTS)2 and Pd(5MCTS)2 exhibited strong inhibitory effects against the 6PGD enzyme with 3.87 and 6.03 µM IC50 values, respectively. Metal complexes increased the inhibition potential of ligands on enzyme activity. The four metal complexes showed inhibition effect with IC50 values between 12-21 µM.