İnsan inflamator sitokinleri (IL-1β ve IL-6) kardiovasküler hastalıklara etkisinin araştırılması

Although deaths due to cardiovascular diseases have decreased in the last 30 years worldwide, they are still among the most common causes of death in North America and Europe. The Turkish Society of Cardiology (TEKHARF) pioneered since 1990, has conducted according to a study data that, two million cases of coronary heart disease were recorded and about 160,000 people are dying from coronary heart disease every year in Turkey. Cytokines are biological mediators that regulate immunological, local, or systemic inflammatory and restorative host responses and act as signals between cells. IL-1β is a type of cytokine that can have multiple effects, such as growth and differentiation, on many cell types simultaneously. In our study, we evaluated a comparison between a patient group (n=39) with cardiovascular diseases and a healthy, who were not previously diagnosed with this disease a control group (n=30) about several risk factors including diabetes, obesity, smoking, and hyperlipidemia and their correlation between Interleukin-1 beta (IL-1β), and cardiovascular diseases. A statistically significant relationship was found between triglycerides and the expression of IL-1β in the study groups (p=0.012). However, the complete statistical analysis of the absence of clear significant differences between the pathological and non-pathological states in most of the studied traits except for triglycerides, and the variables used such as gender, age, weight, BMI have no significant effects, except in very few replications. The relationship of cytokines, which are biological response modifying molecules that can show activity even at very low concentrations, with cardiovascular events is still being investigated.