Investigation of the effects of some Schiff bases and Schiff base metal complexes on alpha-glucosidase enzyme activity

α-glucosidase is an important target enzyme in the fight against type 2 diabetes. With its inhibition, the conversion of monosaccharides to monosaccharides slows down and their rate and rate of mixing into the blood decreases. In this study, it was aimed to investigate the effects of some Schiff bases and Schiff base metal complexes on alpha-glucosidase enzyme activity in vitro and in silico. The α-glucosidase enzyme activity was measured spectrophotometrically at 408 nm. Docking studies were carried out using the Molegro Virtual Docker program. 2D interaction details were determined using the Discovery Studio 2021 Client program. In the study, no inhibition effect was detected on the enzyme activity of ligands. The copper complexes of the ligands exhibited a very strong inhibitory effect. Strong inhibition effects have been detected in palladium complexes. Docking studies have shown that hydrogen bonds, hydrophobic and wan der Waals interactions are effective in the interaction of the molecular with the active site of the enzyme.