The investigation of some drugs by EPR technique
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Özet (EN)
The main purpose of this work was to find out the stability of free radicals induced by irradiating two types of drugs (Lamotrigine & Flurbiprofen) with gamma rays at room temperature (295k) by EPR technique.The two drugs have been irradiated with gamma rays with the energy up to 20 kGy at room temperature and the produced EPR spectrum has been compared to the simulated EPR spectrum before irradiation to find the type of free radicals produced after irradiation. Using the two EPR spectrum, irradiated and un-irradiated, we found out that the two pharmaceutical active ingredients diseases are very sensitive to irradiation in solid state because gamma rays can breakdown the hydrogen and the carbon bonds and the drugs become ions, which means that free radicals are produced.
Yazar
Farhad Hamadameen
Bu Yayına Nasıl Atıf Yapılır
Farhad Hamadameen (Master Thesis). The investigation of some drugs by EPR technique, 2016, Dicle University.
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