Predictors of mortality in patients with COPD related acute respiratory failure requiring mechanical ventilation

Objectives and aimsCOPD, has a high mobidity and mortality and also in acuteattacts treatment may need to continue internal critical care unit. We aimed to investigate the potential factors effecting morbidity and mortality in COPD cases in Univesity of Gaziantep internal critical care unit and companing coclusions with other investigations in literature.Materials and methods: 85 cases accepted to Univesity of Gaziantep internal critical care unit between february 2007-july 2008 with respiratory failure leading COPD aged 65+/- 10.9 are investigated prospectively using university of Gaziantep internal critical care units archieves.(Male:69, female:16)Data analysis: Average time in critical care unit was 6(3-11.5) days and mortality was %39(n:33) in 85 cases included to the observation %59 of cases with IMV and %21 of cases with NIMV mortality outcomed. In %36 (n:4) of females NIMV was not suscessfull and in %2 of females was suscessfull. In %91.3 (n:21) of males NIMV was suscessfull and in %64 of males NIMV was suscessfull. Comorbid diseases (Dibetes Mellutis,Hypertension ) was more in NIMV not suscessfull group. (p:0.05, 0.004). Statisiticly there was no difference among hemodynamic instability, GCS intubated group FEV1 % between two groups. When directly intubated cases and after NIMV intubated compared, GCS was lower in directly intubated group according to after NIMC intubated group and was significant statisticly.Conclusions: Age, gender, APACHE II score, clinic department transferred patient, comorbidities (DM; HT; CAH, Heart failure) , GCS, at the time of acception, necessarity of NIMV or IMV, duration of IMV, reintübation, necessarity of tracheostomy, albumin anf hemotocrits values at tehe time of acception pH, pCO2, base FEV1values during hospitalization were analysed according to univariante regration analysis increased APACHE II score, necessarity of reintubaiton and tracheostomy increased mortality, normal values of hemotocritis, albumin, bicarbonate, carbondioxide and high GCS decreased mortality. According to multivariante regration analysis it is that, these factors do not effect mortality significanty.