DNA repair gene polymorphisms in B cell Non-Hodgkin's lymphoma

Cancer is a group of diseases characterized by frequent DNA injury. Genetic and environmental factors are very important in the etiology of the cancers. It has been detected an association between variabilities in DNA repair capacity and sensitivity to the cancer. We did not find a study about DNA repair gene polymorphism in adult lymphoma cases in our country. In some previous studies, it has been found that NHLin our country is seen 10 years younger than western countries. The aim of our study is to investigate DNA repair gene single nucleotide polymorphisms in B cell NHL.Ninety four casses with NHL and 96 healthy controls were included in this study 60 of the cases (%63,8) had DLBCL, 13 cases (%13,8) had follicular lymphoma, 6 cases (%6,4) had small lymphocytic lymphoma, 6 cases (%6,4) had marginal zone lymphoma and 9 cases (%9,6) had other type of B cell lymphomas. Male/female ratio was 49/45.ERCC2 (Lys751Gln), XPC (Gln939Lys), ERCC5 (Asp1104His) and XRCC3 (Thr241Met) gene polymorphisms were studied in the cases and control groups. Study of XRCC1 Arg399Gln gene polymorphism was planned, but could not be studied due to technical reasons and insufficient funding.ERCC5 Asp1104His polymorphism showed a protective effect against the disease in individuals carrying the mutant allele (p=0,009). This difference was found to be more pronounced in males (p=0,001). The patient and control groups were divided as smoker and nonsmoker and in nonsmoker group, the mutant allele of XPC gene showed protective effect (p=0,040). ERCC2 codon 751, XPC codon 939 and XRCC3 codon 241 gene polymorphisms were not found to be different between cases with NHL and controls (p>0,05). The mutant allele G of ERCC5 (CG) polymorphism in individuals with the G mutant allele as compared with controls showed a protective effect (p=0,010).In conclusion DNA repair gene polymorphisms may affect the risk of lymphoma. Therefore, it will be useful to detect the DNA repair gene polymorphism in cases with lymphoma which is relatively frequent neoplasia in our country.Keywords: Environmental factors, DNA repair genes, lymphoma, sensitivity to cancer, single nucleotide polymorphism