Synthesis of new derivatives of non steroidal anti-inflammatory drugs

Ibuprofen is a molecule which is the first presented in the 2- aryl propionic acid derivatives and the most commonly used. Analgesic, antipyretic and anti-inflammatory activity is weaker than the other 2-aryl propinic acid derivatives. Ibuprofen is used as an active matter in most of the painkiller drugs. The most common side effect of ibuprofen is gastrointestinal complaints.In this study, ibuprofen based which is a non selective against the cyclooxygenase enzyme that a non steroidal anti-inflammatory compound, the new ibuprofen derivatives were synthesized whose anti-inflammatory activity is more than ibuprofen. After determination of the melting points of all synthesized derivatives, their structures were identified by FT-IR and 1H-NMR spectroscopic methods.