The eveluation of pulmonary functions in children with sickle cell anemia

Aim: In this study we included children with sickle cell anemia who were at follow up in our pediatric heamatology clinic and we aidmed to eveluate the relations of these findings with clinical parametersMaterials and Methods: 24 children with sickle cell anemia and 9 children as control group where include to the study. Complete blood count, hemoglobin electrophoresis and biochemical values were eveluated for both groups. At pulmonology depermant the carbonmonoxide diffusion test performing for both groups. At the same day spirometric respiratory function evaluation and exercise test performed to all groups at department of sports physiology. The data recieved are compared statisticsResults: HbS was eveluated 85.2% at sickle cell patient?s hemoglobin electrophoresis. HbS, HbF, SGPT, ferritin, total bilirubine, direkt bilirubine and Fe++ values were high at patient group (p<0.05). Hemoglobin and hematocrit values were low at patient group according to control group (p<0.05). Number of patient?s who had one- three VOC attacks were 14 (58.3%), who had 3 or more VOC attacks were 7 (29.2%) and who had no VOC attacks were 3 (12.5%). Number of patient?s who had ACS were 5 (20.9%) and who had no ACS were 19 (79.1%). İmpaired isole carbonmonoxide diffusion test was established at the 62.5% of the patient?s. At patient group, spirometric FEV1 and MEF25 measurement were lower (p<0.05). At exercise test VO2/HR rate were lower for patient group (p<0.05). VE/VO2 rate (p=0.023) and R (p=0.016) measurement higherConclusion: At patients with severe anemia pulmonary gas transfer could be difficult. Respiratory airways established obstructed in spirometric evelution. Obstructive defficiensies have to be follow up. Oxygen pulse and respiratory exchange rates were eveluated low and more metabolic activity for aerobic oxygen usage was observed. In conclusion, we can say that because of inflamation at lungs due to oxygen radicals and hipoksemia the aerobic respiratory load was increased.Key Words: Sickle cell anemia, carbon monoxide diffusion test, spirometry, exercise tests, aerobicrespiratory, children.