Effects of protease (matri̇x metalloproteinase and systein cathepsin) inhibitors on bond strength of post systems

Aim: Durable prosthetic restorations depend on strong adhesion. Reinforcement of adhesion is important factor for success of glass fiber posts luted root canal by resin cements. Although adhesion of resins to dentin is quite strong, some factors may contribute disadvantages. One of the most important of these factors is degradative effect of dentin protease (Matrix metalloproteinases and cystein cathepsin) on collagen matrix. In this study, researching of effects of different MMP inhibitors and cross linkers on resin-dentin bond strength is aimed. Material and Method: Glass fiber posts are luted by RelyX U200 and RelyX Ultimate resin cements after chlorhexidine, glutaraldehyde and curcumin application to root canal (n: 8). Dentin biomodifications were not applied to negative control groups. Examples were tested after 24 hours and thermal aging by micro push-out bond strength test. Failure patterns were classified by stereomicroscope. Datas were analyzed statistically. Nanoleakage were analyzed by SEM qualitatively. Results: Mean immediate bond strength value of glutaraldehyde group of RelyX U200 is higher than control group. Bond strength values of glutaraldehyde and chlorhexidine is higher than control group after thermal aging. There is no difference between mean immediate bond strength values of RelyX Ultimate. Mean bond strength value of curcumin group is lower than control after aging. Cohesive failure patterns are prominance after thermal aging. Conclusion: Chlorhexidine and glutaraldehyde agents does not effect bond strength of fiber posts luted by RelyX U200 and RelyX Ultimate negatively. Curcumin pretreatment decreases bond strength of RelyX Ultimate resin cement used with 3 step adhesive system.