Evaluation of lipid profile and insulin resistance in patients with psoriasis

Psoriasis is a chronic, multi factorial inflammatory skin disease and has been associated with abnormal lipid metabolism, obesity and insülin sensitivity.In this study, in patients recently diagnosed with psoriasis, or who had not received any systemic treatment for six months and topical treatment for 3 months, we aimed to evaluate lipid profile and insulin resistance after excluding secondary causes that might result in hyperlipidemia and insulin resistance.A total of 48 patients who applied to Dermatology Polyclinic, Medical Faculty, Dicle University between December 2005 and May 2008, and who were diagnosed with psoriasis were included into the study. As control group, 50 healthy subjects were included into the study. Both groups were formed from among individuals with similar characteristics; in terms of sex, age and body mass index. Patients with psoriasis and controls were compared in terms of lipid profile and HOMA ? IR values.There were not any significant difference in lipid profile and HOMA ? IR values between the two groups (p>0,05).In conclusion, statistically, we could not determine any significant difference between psoriasis and control group patients according to their lipid profile and HOMA-IR values. This results supports the opinion that some other factors may be effective in the development of hyperlipidemia and insulin resistance in psoriasis patients.