Pterjiumda ACTR-3 gen ifadesinin analizi

Pterygium is a disorder of the ocular surface defined by uncontrolled cell proliferation, fibrovascular growth that crosses the cornea of the eye and disruption of cell shape and morphology, moreover ACTR-3 is a gene that encodes for one of the major subunits of ARP2/3 complex that help regulate actin assembling in which it gives cell its shape and motility. The purpose of this study is whether there's a link between ACTR-3 gene expression and pterygium development.The study included 18 pterygium patients and 18 volunteers with normal conjuctiva.The expression of the ACTR-3 gene in each group of individuals was evaluated using a quantitative reverse transcription PCR technique.. The result of the study was statistically significant (P=0.015) and there was an increase in ACTR-3 gene (13.62±4.91) in pterygium tissues compare to normal conjuctiva. We concluded that this increase in expression of ACTR-3 gene may have role in pterygium formation.