The effect of antioxidant treatment on endometriotic cyst volume and cell DNA damage on A rat endometriosis model

Endometriosis effects 2 to 10% of the general population but its pathophysiology still remains unknown. Even though endometriosis is a benign disease, malignancy criteria such as, invasion, distant organ involvement and angiogenesis are present. In cases less than %1, malignant transformation is detected. The presence of elevated levels of oxidative stress parameters in patients with endometriosis are well known, nevertheless medical treatment options are limited. In this experimental study, we aimed to investigate the effect of antioxidant treatment(vitamin C and E) on endometriotic cyst volume and cell DNA damage. In this study, a total of 20 Wistar Albino rats, mean weights of 250 gr, were used. Control Group: Autologous endometriosis model + serum physiologic(10 rats) Study Group: Autologous endometriosis model + vitamin C and E(10 rats) Intraperitoneal injections were started after the endometriosis model was completed. At the end of 31 days of study period, weights, endometriotic cyst volume, gland-stroma score and DNA damage(TUNEL(+) percentage) were compared between the two groups. The study was finalized with 11 rats. Analized data did not show any significant difference between groups(p>0.005). Although these differences were short of statistical significance, increasing the scope of the study may alter the results.