Insulin resistance in smokers and nonsmokers

Introduction: Insulin resistance is the decrease sensitivity of tissues in the body to insulin effect. Obesity, advanced age, sedantary life and smoking are the factors leading to an increase in insulin resistance. In our study we aimed to evaluate the relationship between the insulin resistance and smoking in individuals without advanced age, obesity, high blood glucose levels and hypertensionMaterial-Method: We included in this study 100 patients (50 non-smoker, 50 smoker) who admitted to internal medicine outpatient clinic of Duzce University School of Medicine, from February 2009 to July 2009. Patients waist / hip ratio, body mass index, systolic and diastolic blood pressure, triglyceride, LDL cholesterol, HDL cholesterol, fasting blood glucose, insulin, HbA1c were measured. HOMA values were calculated.Results: Between both groups, body mass index, systolic and diastolic blood pressure, triglyceride, LDL cholesterol, fasting blood glucose, insulin, HbA1c and HOMA values were similar (p>0.05). HDL cholesterol levels in smokers compared to non-smokers was statistically significant (p<0.05). In stepwise multiple linear regression analysis, triglyceride and waist / hip ratio were identified as an important independent predictor of an increase in HOMA in smokersDiscussion: Our study have shown that there is no relationship between cigarette smoking and insulin resistance. We are in thought of that the presence of cigarette smoking with conditions causes increase in insulin resistance such as the advanced age, obesity, genetic predisposition, sedentary life and abnormal blood glucose levels can contribute to an increase in insulin resistance.Key words : Cigarette, HOMA, insulin resistance