Coagulation profil of talasemia patients

Introduction and Aim: Thalasemia Disease (TD) is hematologic system disorder and genetic origin which most common in the world and can causative massive result . İn this study our aim is; reconstition an approach in following and treatment which seen hematological complications about kuagulation system in TD.Cases and Mmetodhs: İn this study; 27 thalasemic patients who had been orderly transfüsed and following and terated in our peadiatric hematology unit compared with healthy 20 child. İn thalasemi patients and control group biochemical parameters has been studied in Dicle Universty Biochemistry Laboratory and finding of the patients retrospectively were detected in their files.We determine our patients and control group ultrasonographical examination in our hospital. The statistical analysis for obtained data of patients and control group was built in the packet program of SPSS for Windows 12.0Findings :In thalasemic patients compared with control group ;the levels of Iron and Ferritin were found increased and the levels of ıron-binding capacity were found decreased. All the thalasemic patients hepatosplenomegaly were found in sonografical examination and this data most significant statistically(P?0,05).The marker of Hepatic disease like ALT and AST werefound increased in patients compared with control group and this data most significant statistically(P?0,05). Levels of the Protein C and Proten S were found decreased and levels of Factor 8 and VWF were found increased. When compared with control group this data most signicant statistically(P?0,05).Levels of Protein C and Protein S were found negative corelatin with level of Ferritin(P?0,05).Results: İn thalasemic patients orderly transfüssion and with compliance of thalasemic patients to chelation therapies and development of medical knowledge; a lot of compliacations were determined which had been not reportred. İn our study ; in our thalasemic patients hepatic disorder were found increased. Levels of Protein C and Protein S depend on hepatic disease were decreased. Level of VWF and Factor 8 were found increased and with this findings in thalasemic patients hipercoagulabilite state is most important problem. Pathogenesis of hypercoagulabilite state is unknown yet but the presence of hiperkuagülabil state in thalasemic patients must to be considerable every times .Key words: Thalasemia, Hypercoagulation