The assesment of the serum prostate spesific antigen in ti 2 diabetics patients

Introduction: Risk of the prostate cancer is associated with high insulin levels in circulation and insulin resistancy. There are some studies that suggested lower risk in diabetics due to decreased insulin levels. In this study we aimed assesment of serum PSA levels in diabetics men age of 50 and overMatherial- Methods: 137 patients age over 50 years ( 67 case, 70 control) admitted to Duzce University School of Medicine outpatients clinic from March 2008 to Novenber 2008 have been included in this study. Case and control groups were divided three groups as their age ( 50-59 years, 60-69 years and >70 years). PSA values were compared between in these age groups. Moreover, case group were divided three groups as their diagnosed diabet time ( 0-5 years, 6-10 years, >10 years) and these group?s PSA values were compared. Patients with BPH, prostatitis and prostate cancer were not inclded in this studyResults: Serum mean PSA values of diabetic patients age of 50-59 years was 0.76 ± 0.35 ng/mL and it was found lower than same age group of non-diabetic patient?s serum PSA values (1.08 ± 0.75 ng/mL) (p<0.05). Similary in age groups of 60-69 years, diabetic patient?s PSA values were found significiently lower than non-diabetic patient?s PSA values ( in order1.17 ± 0.43 and 1.77 ± 1.15 ng/mL ) (p<0.05). Between over age of 70 years groups and between diagnosed time of diabet groups, serum PSA values were not found significiently different (p>0.05Conclusions: We found serum PSA levels sigificiently lower in diabetic groups than non-diabetic groups age of 50-59 years and 60-69 years. We couldn?t find istatically difference between PSA and diagnosed time of diabet. Consequently, prostate cancer risk may be lower in diabet patients than non-diabeticsKey words: Diabet, PSA , age