Investigation of the Serum Visfatin, Fetuin A and Eotaxin Levels İn Patients With Type 2 Diabetes Mellitus

Adipose tissue, secretes metabolically active many molecules that known as adipokin. Some of these have been found associated with obesity, insulin resistance and type 2 diabetes. Visfatin is the one of adipokines secreted by visceral adipose tissue especially and has been specified to be associated with type 2 diabetes. Eotaxin is located in visceral adipose tissue and produced by certain cells of the immune system that has a role involved particularly allergic and inflammatory reactions and it has been identified as a proinflammatory cytokin. In addition to this, it has been suggested that eotaxin to be associated with insulin resistance and diabetes. Fetuin A is another protein molecule secreted from the liver that it may be associated with obesity, insulin resistance and type 2 diabetes. However, the results of the research done so far are not enough to explain the relationship of obesity, insulin resistance and diabetes mellitus with visfatin, eotaxin and fetuin A. Moreover, the results of research on this subject does not present a complete harmony. Therefore, in this study; we measured serum levels of visfatin, eotaxin and fetuin A in obese and non-obese type 2 diabetic patients treated medically. And we examined the possible relationship these parameters both diabetes and between them The study was carried out in 30 T2DM patients with varying ages between 47-83 and 20 sex and age matched healthy volunteers control subjects (n=20). According to the body mass index (BMI) 30 patients were divided into two subgroups; one group was non-obese diabetic patients with 18.50