Türk popülasyonunda over kanseri hastalarında kemokin ligant 12 (Cxcl12) gen polimorfizminin etkisinin araştırılması

Ovarian cancer is considered the eighth killer cancer in women globally. In 2021, about 4059 women were identified as ovarian cancer cases, and 2730 of them were reported as cancer deaths in Turkey. It is relatively uncommon, but it has a high death rate among women due to its being hard to detect at early stages when there are no reliable screening methods. Therefore, most of the patients presented at advanced stages with metastasis. Ovarian cancer is a heterogeneous polygenic disease in which there are numerous morphological and molecular types of ovarian cancer. Several gene mutations are involved in the molecular pathogenesis of ovarian cancer.Chemokine ligand 12 (CXCL12) is a chemokine that acts as a ligand for chemokine (C-X-C motif) receptor 4 (CXCR4). The CXCL12 gene is expressed in normal and ovarian cell cancer. Both CXCL12 and CXCR4 are involved in ovarian carcinogenesis through enhanced tumor cell growth, angiogenesis, and metastasis. This thesis study aims to investigate the possible association between SNP rs1801157 in CXCL12gene and susceptibility to ovarian cancer among the Turkish population. The two groups were investigated (n = 40) ovarian cancer patients and the (n = 47) control group, using real-time PCR and statistical analysis of data was performed by the SPSS program. We focused on the genotypic and allelic distribution of this SNP. According to our findings, homozygote wild type (CC), heterozygote (CT), and homozygote mutant type (TT) rates are calculated respectively as 44.7%, 46.8%, and 8.5% in the control group. However, homozygote wild type (CC), heterozygote (CT), and homozygote mutant type (TT) rates are determined respectively as 42.5%, 47.5%, and 10% in the patients' groups. There was no significant relationship between genotypes in patients and the control group subjects under study. We obtained a p-value of (0.962) Keywords: Ovarian Cancer Chemokine ligand 12, CXCL12,SNP, Genotypes