Genetics studies in patient who has reproductive problems

SUMMARY GENETICS STUDIES IN PATIENT WHO HAS REPRODUCTIVE PROBLEMS The aim of this study is to evaluate the correlation of chromosomal aberrations and some other genetics and non genetics related factors, with reproductive problems in males and females. The patients who have been prediagnosed as reproductive problems were screened for chromosomal aberration. Chromosome analysis of 245 prediagnosed patient were realised by harvesting chromosomes from peripheral lymphocyt culture and prepared by GTG and HRB technics, and than scored under the microscope by 10X and 100X magnification. The rate of major chromosomal abnormality were found as 6.53% (16/245) in total of 245 individual. This rate raised to 11.42 % in addition of minor polymorphic chromosomal variants. Major chromosomal abnormality incidence were found as 2,19 % in the groups of who has reccurrent abortion, 23 % in females group and 17.64 % (3/17) in males group. The rate of minor polymorphic chromosomal variants is found to be 4.89 %. The first group which consisted the couples with fetal wastage showed 8.79 % of minor polymorphic chromosomal variants. The effects of other genetics and nongenetics related factors on reproductive problems, were checked by pedigree analysis. No corelation were found; between the rate of consanguinity of the parents, addiction to cigarettes and the number of abortions, stillbirths, congenital anomalies and child deaths. The finding of our study indicate that; within the etiologic factors of reproductive problems, chromosomal abnormalities have an important role and especially women who have reproductive problems should be checked cytogeneticly.